What is Cialis?
Cialis is the brand name of Tadalafil, a prescription medication used to treat two main conditions in men: erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). It belongs to a group of medicines known as PDE-5 inhibitors, which improve blood flow by relaxing blood vessels. In Pakistan, Cialis is commonly prescribed to married men looking for a reliable treatment for sexual performance and urinary problems caused by prostate enlargement.
Cialis Uses: FDA-Approved and Off-Label
Cialis (Tadalafil) is an FDA-approved prescription medicine for adult men. It is officially used to treat three conditions:
- Erectile Dysfunction (ED)
- Benign Prostatic Hyperplasia (BPH)
- Combined ED and BPH symptoms
Doctors may also prescribe Cialis off-label for other conditions based on clinical judgment. Off-label use means the medicine is being used for a purpose that’s not officially approved but is supported by medical research or practice.
Cialis for Erectile Dysfunction (ED)
ED is the inability to achieve or maintain an erection that’s firm enough for sex. It can be caused by:
- Certain physical health conditions, such as diabetes or hypertension
- Nerve or blood flow problems
- Psychological stress, anxiety, or depression
Cialis works by improving blood flow to the penis during sexual stimulation. It doesn’t cause an erection on its own but helps the body respond naturally to arousal.
Effectiveness
Researchers evaluated Cialis by using the International Index of Erectile Function (IIEF) questionnaire to assess its effectiveness. Men taking Cialis showed a significant improvement in their IIEF scores, indicating better erections and increased sexual performance compared to those taking a placebo.
This was true for both.
- On-demand use (taking it before sexual activity)
- Daily use (low-dose Cialis taken once daily)
Cialis for Benign Prostatic Hyperplasia (BPH)
Benign Prostatic Hyperplasia (BPH) is a non-cancerous increase in the size of the prostate gland, commonly seen in older men. As the prostate grows, it can press against the urethra and cause uncomfortable urinary symptoms like
- Frequent urination, especially at night
- Weak or interrupted urine flow
- Difficulty starting urination
- Urgency to urinate
- Feeling that the bladder doesn’t fully empty
Cialis helps relax the smooth muscle in the prostate and bladder, improving urinary flow and reducing BPH symptoms.
Effectiveness
In clinical studies, Cialis significantly improved BPH symptoms. Researchers measured changes using the International Prostate Symptom Score (IPSS), a questionnaire that tracks the severity of urinary problems. A lower score means fewer symptoms.
Patients who took Cialis reported a more significant drop in their IPSS scores than those who took a placebo, meaning Cialis helped reduce the number and intensity of urinary symptoms.
Cialis for ED and BPH Together
Cialis is also authorized for use in treating erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) simultaneously. Though these conditions are not directly related, they often occur together in older men.
Some BPH medications like dutasteride may worsen sexual function, but Cialis helps relieve urinary symptoms and supports erectile function.
Effectiveness
Clinical studies showed that Cialis led to improvements in both IPSS scores for BPH and IIEF scores for ED in men experiencing both conditions.
- Patients saw better urine flow and fewer urinary symptoms
- They also experienced stronger, longer-lasting erections
Cialis offers a dual benefit and simplifies treatment for men dealing with both issues simultaneously.
Off-Label Use: Cialis for Ureteral Stones (Kidney Stones)
While not officially approved by the FDA for this use, doctors may prescribe Cialis off-label to assist in passing ureteral stones — kidney stones that have traveled into the ureter, the tube connecting the kidneys to the bladder.
Effectiveness
A clinical trial comparing Cialis to tamsulosin (Flomax) found that more people passed their stones with Cialis. This is likely because tadalafil relaxes the ureter muscles, making it easier for stones to pass.
Doctors may consider this treatment in cases where ureteral stones are small and other medical conditions are managed.
Cialis Dosage
The correct dosage of Cialis (Tadalafil) depends on several factors, including the condition being treated, the severity of symptoms, the patient’s age, and overall health. Doctors usually start with a low dose and adjust it based on response and tolerance. The goal is to prescribe the lowest effective dose.
Cialis comes in tablet form and is offered in four different strengths: 2.5 mg, 5 mg, 10 mg, and 20 mg. It should never be taken more than once in a 24-hour period unless specifically advised by a healthcare provider.
Dosage for Benign Prostatic Hyperplasia (BPH)
For managing urinary issues due to prostate enlargement, the usual recommended dose of Cialis is 5 mg once daily. It’s important to take it at the same time every day to maintain steady results.
In certain cases, doctors may prescribe Cialis together with finasteride (Proscar) to enhance the treatment of BPH symptoms. This combined approach is typically followed for up to 26 weeks under a doctor’s guidance.
Dosage for Erectile Dysfunction (ED)
There are two main approaches for using Cialis to treat ED:
1. Cialis as Needed
When used occasionally for ED, the typical starting dose is 10 mg taken 30 to 60 minutes before anticipated sexual activity.
This dose can be
- Reduced to 5 mg if the effect is too strong or side effects occur
- Increased to 20 mg if the initial dose is not effective
The effects of Cialis can last for as long as 36 hours, but it should not be used more than once within 24 hours.
2. Cialis for Daily Use
For men who choose ongoing treatment, Cialis is taken once daily at a dose of either 2.5 mg or 5 mg. It should be taken at the same time each day, whether or not sexual activity is planned. This approach supports more natural and spontaneous intimacy.
Dosage for Both ED and BPH
When treating both erectile dysfunction and benign prostatic hyperplasia together, the standard dose is 5 mg taken once daily at a consistent time.
Higher Dosages
Cialis is approved in doses ranging from 2.5 mg to 20 mg, depending on the treatment plan. Doses higher than 20 mg per day have not been clinically studied and may cause serious side effects, including dangerously low blood pressure.
Patients should never increase their dosage on their own. Always consult a healthcare provider before making any changes to the treatment.
Missed Dose
If you forget your daily dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed one. Do not take two doses on the same day. For better adherence, consider setting reminders or using a medication tracker.
Long-Term Use
Cialis may be used long term, especially for managing BPH. For ED, long-term use depends on the cause. If ED is caused by stress, an illness, or another treatable condition, Cialis may be stopped after the underlying issue is resolved. Treatment duration should always be discussed with a doctor.
A Guide to Cialis Variants: Black, Gold, Silver, and White Tablets Explained
Cialis is a trusted name in the treatment of erectile dysfunction (ED), known for its long-lasting effects and ability to boost sexual confidence. Over time, multiple Cialis variants have been introduced, each offering unique benefits tailored to different user needs. Whether you’re new to ED medication or looking for enhanced performance, this guide helps you choose the right version of Cialis.
Cialis Black – Maximum Power for Maximum Performance
- Designed for: Men who want strong and long-lasting results
- Typical Strength: Higher doses, often 40mg or more
Key Benefits:
- Enhanced stamina and sexual performance
- May last longer than standard Cialis
- Popular among experienced users
Best For: Cialis Black tablets are Ideal for men who have already used ED medications and want a more powerful boost in performance.
Cialis Gold – Premium Experience, Long Duration
- Designed for: Men seeking a premium, longer-lasting experience
- Typical Strength: 20mg to 40mg
Key Benefits:
- Long-lasting effects (up to 36–48 hours)
- Reliable performance for the entire weekend
- Boosts self-assurance during intimacy
Best For: Cialis Gold Tablets are Perfect for men who prefer peace of mind during extended romantic periods or weekend plans.
Cialis Silver – Gentle Yet Effective
- Designed for: Men who want a mild yet reliable effect
- Typical Strength: 10mg or 20mg
Key Benefits:
- Softer effect with fewer side effects
- Suitable for first-time users
- Supports confidence-building in a natural way
Best For: Cialis Silver Tablet is a Great option for beginners or those who want a lighter and more manageable ED treatment.
Cialis White – Everyday Confidence with Low Dose
- Designed for: Men who prefer a daily, steady solution
- Typical Strength: 2.5mg or 5mg (daily use)
Key Benefits:
- Taken daily, no need to plan around intimacy
- Promotes spontaneous performance
- Maintains stable levels in the body
Best For: Cialis White is best suited for men who want consistent support without taking a tablet before each encounter.
How Cialis Works | Mechanism of Action for ED and BPH
Cialis (Tadalafil) is a prescription medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and cases where both conditions occur together. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which work by relaxing smooth muscles and increasing blood flow in specific areas of the body.
Erectile Dysfunction (ED): How Cialis Helps
An erection happens when blood flows into the penis and is held there, allowing a firm and lasting erection suitable for sexual activity. This process is controlled by a natural chemical in the body called cyclic guanosine monophosphate (cGMP). It helps by relaxing the smooth muscles in the penis, which improves blood flow and supports achieving and maintaining an erection.
In men with ED, this process is disrupted, either due to poor blood circulation, nerve issues, or psychological factors. An enzyme called PDE5 breaks down cGMP too early, leading to weak or no erections.
Cialis works by blocking the PDE5 enzyme, allowing more cGMP to build up. As a result:
- The blood vessels in the penis relax
- Blood flow increases
- A stronger, more natural erection is achieved during sexual arousal
Benign Prostatic Hyperplasia (BPH): How Cialis Helps
BPH is a condition where the prostate gland becomes enlarged, often due to age. This can press against the urethra and lead to urinary symptoms such as:
- Frequent urination
- Difficulty starting urination
- Weak urine stream
- Night-time urination
Although the exact way Cialis helps is not fully understood, it is believed to relax the muscles in the bladder and prostate, which can ease the pressure and improve urine flow.
How Long Does Cialis Take to Work?
Cialis usually starts to take effect about 30 minutes after the dose is taken. However, for some men, it may take up to 6 hours to feel full effects, depending on metabolism and other factors.
The drug reaches peak concentration in the body about 2 hours after ingestion. This is when its effects are usually strongest, making it suitable for both on-demand use and daily therapy.
Cialis Side Effects: What You Should Know Before Use
As with any medication, Cialis (Tadalafil) may cause side effects in some individuals. While most are mild and short-lived, a few can be severe and may need prompt medical care.
Seek Immediate Medical Attention If You Experience:
- Skin rash or hives, especially with swelling of the face, lips, tongue, or throat
- Trouble breathing
- Chest pain, dizziness, or nausea during sexual activity
- A painful erection or one that lasts longer than 4 hours
- Sudden vision loss or noticeable changes in eyesight
- Ringing in the ears or partial hearing loss
- Symptoms of a heart attack, such as chest pain spreading to your jaw or shoulder, sweating, or difficulty breathing
These may be signs of a severe allergic reaction or dangerous cardiovascular response, and you should stop using Cialis and contact a doctor immediately.
Common Side Effects of Cialis
Some side effects occur more frequently and often resolve on their own without the need for medical treatment. These include:
- Headache
- Flushing or warmth in the face
- Indigestion or upset stomach
- Nasal congestion or stuffy nose
- Back pain
- Muscle aches or body pain, especially in the arms or legs
- Nausea
These symptoms usually ease within a few hours or days. Staying hydrated, getting adequate rest, or adjusting the dosage under medical supervision can help relieve the discomfort.
Important Note
The risk of side effects may increase:
- In older adults
- With higher doses (such as 20 mg)
- When combined with alcohol or certain medications
Always follow your doctor’s dosage instructions and never self-medicate or exceed the recommended amount.
Cialis Compared to Other Medications: Viagra, Levitra (Vardenafil), and Adcirca
Many men ask how Cialis (Tadalafil) compares with other erectile dysfunction (ED) medications like Viagra (Sildenafil) and Vardenafil (Levitra). Although these medicines are used for similar purposes, they have differences in ingredients, how long they last, side effects, and cost.
Cialis vs Viagra
Active Ingredients:
- Cialis: Contains Tadalafil
- Viagra: Contains Sildenafil
Both drugs are part of the PDE5 inhibitor group, which enhances blood flow to the penis in response to sexual stimulation.
Uses:
- Both drugs are FDA-approved for Erectile Dysfunction (ED)
- Cialis is also approved for Benign Prostatic Hyperplasia (BPH) and for treating ED + BPH together
- Viagra is used only for ED
Dosage and Use:
- Cialis offers flexible dosing options — it can be taken daily in doses of 2.5 to 5 mg, or on an as-needed basis with 10 to 20 mg.
- In contrast, Viagra is usually taken only when needed, about 30 to 60 minutes before sexual activity.
Duration of Action:
- Cialis can remain effective for up to 36 hours, offering greater flexibility in the timing of sexual activity.
- Viagra usually lasts around 4–6 hours
Common Side Effects:
Both can cause:
- Headache
- Flushing
- Stuffy nose
- Back or muscle pain
- Nausea
- Dizziness
Viagra may also cause abnormal vision (blue tint). Cialis may cause pain in the arms or legs and heartburn.
Serious Side Effects (Both):
- Prolonged erection (more than 4 hours)
- Vision or hearing changes
- Allergic reactions
- Sudden drop in blood pressure
Effectiveness:
Studies show both medicines work well for ED. However, some research found:
- More men preferred Cialis because of its longer-lasting effect
- Men using Cialis felt less pressure about timing during intercourse
- IIEF scores (a measure of erectile function) improved similarly in both groups
Cost:
Both have generic versions:
- Cialis: Tadalafil
- Viagra: Sildenafil
Generics are more affordable than the brand-name versions.
Cialis vs Vardenafil (Levitra)
Active Ingredients:
- Cialis: Tadalafil
- Vardenafil: Generic version of Levitra
Both are PDE5 inhibitors
Uses:
- Both are approved to treat ED
- Cialis is also approved to treat BPH and ED + BPH
Dosage and Use:
- Cialis: Once daily or as needed
- Vardenafil: Taken as needed only
Side Effects:
Common side effects (shared):
- Headache
- Flushing
- Stuffy nose
- Back pain
- Muscle aches
- Dizziness
- Nausea
Serious side effects (both):
- Prolonged erection
- Vision or hearing changes
- Allergic reactions
- Changes in blood pressure
Effectiveness:
Both are effective for ED and work similarly in clinical studies.
Cost:
- Vardenafil (generic) is usually cheaper than Cialis
- Generic Cialis (Tadalafil) is widely available and more affordable than the brand version
Cialis vs Adcirca
Both Cialis and Adcirca contain the same active ingredient: Tadalafil, but they are approved for very different medical conditions.
Uses:
- Cialis: For ED, BPH, or both ED and BPH
- Adcirca: For pulmonary arterial hypertension (PAH) – a rare lung condition involving high blood pressure in the lungs
Dosage and Administration:
-
Cialis: 2.5 mg to 20 mg per day or as needed
-
Adcirca: Typically 40 mg per day for PAH patients
Important Note:
These medications are not interchangeable and should only be used as prescribed by a healthcare professional. Taking Adcirca instead of Cialis (or vice versa) without medical approval is unsafe and may not work for the intended condition.
Cialis Interactions with Medications, Foods, and Supplements
Before starting Cialis (Tadalafil), it’s important to understand how it may interact with other drugs, supplements, or even certain foods. Some interactions can increase the risk of side effects or reduce the effectiveness of the medication. Always discuss your complete medication list with your doctor or pharmacist.
1۔ Interactions with Medications
The following medications may interact with Cialis and should be discussed with your doctor before use:
Nitrates:
Avoid using Cialis with nitrate-based medications commonly prescribed for chest pain (angina), as this combination can lead to a serious and unsafe drop in blood pressure.
Common nitrates include:
- Nitroglycerin
- Isosorbide mononitrate (Monoket)
- Isosorbide dinitrate (Isordil)
If you’re given nitrates during a medical emergency, your doctor will monitor you closely, especially if it’s been less than 48 hours since your last Cialis dose.
Alpha-blockers
Alpha-blockers are used to manage BPH and high blood pressure, but they may also reduce blood pressure further, which can lead to dizziness or fainting. Taking them with Cialis increases the risk of dizziness or fainting due to low blood pressure.
Common alpha-blockers:
- Tamsulosin (Flomax)
- Alfuzosin (Uroxatral)
- Doxazosin (Cardura)
Your doctor might modify your Cialis dosage or advise against using it alongside certain medications, depending on your health condition.
Blood Pressure Medications
Cialis can slightly lower blood pressure. If you’re taking other antihypertensive drugs, combining them with Cialis may cause symptomatic hypotension (very low blood pressure).
Examples:
- Amlodipine (Norvasc)
- Metoprolol (Toprol XL, Lopressor)
- Enalapril (Vasotec)
Antacids
Over-the-counter antacids can reduce your body’s ability to absorb Cialis properly, which may make it less effective.
Examples:
-
Calcium carbonate (Tums)
-
Aluminum/magnesium hydroxide (Mylanta)
Take Cialis and antacids at different times as advised by your doctor.
CYP3A4 Inhibitors
Cialis is metabolized by the liver enzyme CYP3A4. Some drugs block this enzyme, leading to higher levels of Cialis in the body, which may raise the risk of side effects.
Examples:
- Ketoconazole (antifungal)
- Itraconazole (Sporanox)
- Erythromycin (antibiotic)
- Ritonavir (HIV medication)
CYP3A4 Inducers
On the other hand, enzyme inducers speed up how quickly Cialis is broken down. This may make Cialis less effective.
Examples:
- Rifampin (Rifadin)
- Carbamazepine (Tegretol)
- Phenytoin (Dilantin)
- Phenobarbital
In such cases, your doctor may consider a different ED treatment.
Guanylate Cyclase Stimulators
Medications used to treat pulmonary hypertension should not be combined with Cialis, as this can result in a dangerously low drop in blood pressure.
Example:
-
Riociguat (Adempas)
If you’re on these medications, your doctor will recommend an alternative to Cialis.
2. Interactions with Supplements and Herbal Products
Although no herbal supplements are officially known to interact with Cialis, it is still important to consult your doctor before using any of the following:
- Herbal sexual enhancers
- Stamina boosters
- Over-the-counter supplements
Some supplements may influence blood pressure or interfere with prescription medications.
3۔Cialis and Food Interactions
Here are some foods that interact with Cialis:
a. Alcohol
Cialis and alcohol both lower blood pressure. Drinking large amounts of alcohol while using Cialis can increase the risk of:
- Dizziness
- Headache
- Rapid heart rate
- Fainting
Limit alcohol use when taking Cialis to reduce the risk of side effects.
b. Grapefruit
Avoid grapefruit and grapefruit juice while using Cialis. Grapefruit blocks the CYP3A4 enzyme, which slows down the breakdown of Cialis. This leads to higher drug levels in your body, increasing the risk of:
- Headaches
- Low blood pressure
- Prolonged erections
- Dizziness
Cialis Precautions: Who Should Be Careful?
Before starting Cialis (Tadalafil), make sure to share your full medical history with your doctor. Some health issues or risk factors could make this medication unsafe or raise the risk of serious side effects. Be mindful of the following conditions:
Heart Conditions
Cialis can affect your cardiovascular system, especially during sexual activity, which increases heart workload. If you’ve had a heart attack, irregular heartbeat, or heart failure, consult your doctor before taking Cialis. Stop using the medication and seek emergency help if you feel chest pain or palpitations during sex.
Pulmonary Hypertension
Do not use Cialis if you are being treated with riociguat (Adempas) for pulmonary arterial hypertension, as combining these medications can lead to a serious and unsafe drop in blood pressure.
Blood Pressure Issues
Cialis may cause either high or low blood pressure. If you already have blood pressure disorders, your doctor may monitor you more closely or adjust the dose.
Stroke History
If you have a history of stroke, using Cialis might not be suitable for you. Research has shown a possible connection between Cialis and a higher risk of stroke in people with heart-related conditions. It’s essential to undergo a detailed medical assessment before starting this medication.
Liver Disease
People with liver conditions (like hepatitis or cirrhosis) may not process Cialis properly. The medication can accumulate in the body and raise the risk of side effects. Your doctor may start you on a lower dose or suggest an alternative.
Kidney Problems
If you have chronic kidney disease or reduced kidney function, Cialis may not be eliminated from your system efficiently. This can lead to drug buildup and side effects. A reduced dose may be necessary.
Eye Conditions
Avoid Cialis if you have a history of sudden vision loss, especially from conditions like non-arteritic anterior ischemic optic neuropathy (NAION). It could worsen vision problems or increase your risk of permanent damage.
Retinitis Pigmentosa
This is a genetic eye disorder that can cause gradual vision loss. Cialis is not recommended for people with this condition due to a higher risk of eye-related side effects.
Stomach Ulcers
If you’ve had stomach or intestinal ulcers, Cialis might raise the risk of gastrointestinal bleeding. Consult your doctor before starting the medication.
Bleeding Disorders
Conditions such as hemophilia or a history of abnormal bleeding can worsen with Cialis use. Your healthcare provider may recommend an alternative treatment.
Deformed Penis or Peyronie’s Disease
People with Peyronie’s disease or any structural abnormalities of the penis are at a higher risk for complications such as priapism (a prolonged, painful erection). Caution is advised.
History of Prolonged Erections (Priapism)
Cialis may raise the risk of prolonged erections lasting more than 4 hours. If you have a history of priapism (a persistent, painful erection), be sure to inform your doctor. This condition is a medical emergency and requires prompt treatment to prevent long-term damage.
Blood Cell Disorders
Diseases like sickle cell anemia, leukemia, or multiple myeloma can also raise the risk of prolonged erections when taking Cialis. A low dose or close monitoring may be necessary.
Allergies
Avoid using Cialis if you are allergic to tadalafil or any of the other ingredients in the tablet. Allergic reactions may include symptoms such as rash, itching, swelling, or trouble breathing.
Conclusion:
Cialis (Tadalafil) has become a trusted option for men in Pakistan seeking treatment for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), or both. Its long-lasting effect, flexibility in use (daily or on-demand), and dual benefits for sexual and urinary health make it a preferred choice over many other ED medications.
However, like any medicine, Cialis must be used responsibly. Always consult your doctor before starting, especially if you have heart issues, vision problems, or take other medications. With proper guidance and use, Cialis can significantly improve quality of life, confidence, and overall wellbeing in intimate relationships.
Common Questions About Cialis
These pills are a widely used medication for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). If you’re considering using Cialis or already taking it, you might have several questions about its safety, usage, and effects. Below are some of the most frequently asked questions to help you understand how Cialis works and what to expect.
Can women take Cialis?
It is intended only for use in men and is not approved for women. It is prescribed to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) in males. For women experiencing low sexual desire, other treatments such as Bremelanotide (Vyleesi) or Flibanserin (Addyi) may be considered. Always consult a healthcare professional to explore suitable treatment options.
Does Cialis work, and is it safe?
Yes, Cialis is FDA-approved and considered safe and effective for most men. However, people with heart conditions or those taking certain medications (like nitrates) should avoid it. Always share your medical history with your doctor before starting Cialis.
Can Cialis help maintain an erection even after ejaculation?
No, Cialis doesn’t maintain an erection after ejaculation. However, because it stays active in the body for up to 36 hours, it may help you achieve another erection later if sexual stimulation occurs again.
How long does Cialis stay in your system?
Cialis remains active in the body for over 48 hours, offering extended flexibility for sexual activity. Because of its long-lasting effects, it’s often referred to as the weekend pill.
Can Cialis be used after prostate surgery?
Yes, Cialis can be effective for treating ED after prostate surgery. Clinical studies have shown improved erectile function in men who took Cialis post-surgery compared to those who took a placebo.
Does Cialis increase penis size?
No, These pills does not increase penis size. However, it can improve blood flow, which may result in firmer and fuller erections, especially if previous erections were not complete.
Can Cialis treat premature ejaculation?
Cialis (Tadalafil) is not approved to treat premature ejaculation (PE). It is mainly used for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). However, in some cases, men with both ED and PE may experience improvement in ejaculation control indirectly because Cialis helps maintain an erection longer. But it is not a direct treatment for PE.
Better Options for PE Treatment:
- Dapoxetine (EverLong tablets) (a short-acting SSRI) is specifically approved for PE.
- Behavioral therapy, desensitizing sprays, and counseling are also helpful.